How to play Exploding Kittens with two or three players.Part of the card game’s explosive success is down to how easy it is to learn how to play Exploding Kittens, taking only a couple of minutes to learn the rules, set everything up and get playing. Exploding Kittens is one of the most popular party games of recent years, thanks to its silly premise and cartoon artwork by The Oatmeal creator Matthew Inman.